Castle Creek Pharma has assembled a robust and well diversified portfolio of innovative and high potential late stage drug candidates in development for the treatment of a number of important diseases. Castle Creek Pharma’s products are advancing rapidly through development and have the potential to enter the market within 2-3 years.
Epidermolysis Bullosa Simplex
- Epidermolysis bullosa simplex (EBS) is the most common form of epidermolysis bullosa, a rare dermatologic condition where patients (many of them children) have a genetic defect that compromises the structural integrity of their skin, making it particularly fragile and prone to blistering throughout their bodies. The disease can be severely debilitating and there are no treatment options currently available.
- CCP-020 (diacerein 1% ointment) is a new drug in development for the treatment of EBS. It is a potentially disease modifying therapy that blocks an important inflammatory signaling pathway in EBS.
- The DELIVERS study is evaluating the safety and efficacy of CCP-020 (diacerein 1% ointment) for the treatment of EBS. For more information, visit http://deliversebs.com/ or see the study listing at ClinicalTrials.gov.
Other High Medical Need
Premalignant Oral Lesions
- Oral cancer accounts for approximately 3% of all malignancies in the United States, and approximately 25,000-30,000 cases of oral cancer are diagnosed each year. In addition, oral cancer is one of the most common malignancies in Southeast Asia, accounting for up to 30-40% of all malignancies in India. Despite recent medical advances, the 5-year survival rate for oral cancer is only 50-60%. Many oral squamous cell carcinomas develop from premalignant oral lesions, which include leukoplakia, erythroplakia, and oral lichen planus. The rate of progression to malignancy has been reported to be as high as 17.5%.
- CCP-042 is in development for the treatment of premalignant oral lesions.